Floridians over age 18 who are breast cancer survivors, but are not positive for either the BRCA 1 or BRCA2 genetic mutations are invited to participate in a research study looking for new genetic risk factors for breast cancer.
The study is titled Genomic Analysis of Breast Cancer Risk. Co-sponsored by the Susan Love Foundation, the principal investigator is Harry Ostrer, MD, Professor of Pathology and Pediatrics at the Albert Einstein College of Medicine, Bronx, New York.
This is a rare opportunity for those who fit the criteria for the project to help researchers discover genetic mutations linked to breast cancer that up to now have been unknown.
Two separate groups will be enrolled in the study:
• Group 1 Family Cases – These are women with breast cancer who have at least three family members with breast cancer (including DCIS) and/or ovarian cancer on the same side of the family. In addition, at least one of those affected family members must also be willing to participate in the study.
• Group 2 Very Young (Sporadic Cases) – These are women with no family history, but have been diagnosed with breast cancer before age 35. Present age is not an issue. Ideally, the parents of this individual (if living) will be willing to participate in the study as well.
Since the Human Genome Project was completed in 2003, geneticists have been able to use sequencing tools to look for potential genetic risk factors for various diseases including a number of cancers.
The more individuals are willing to participate in this kind of project, the more data researchers will have to link specific mutations to specific cancer risks.
Those who sign up for the study will be contacted by email and asked to fill out an online eligible survey. For those signing up for Group 1, at least one other family member must be willing to participate.
Prior to acceptance, there will be a one- hour pretest genetic counseling and consent appointment by phone during which the counselor may ask additional health questions as well as questions about the health and genetic information of family members.
In addition to a blood sample, those enrolled in the study will be asked to provide medical records that include their BRCA test reports, pathology reports from the breast cancer surgery, as well as information about specific cancer treatments.
There is no cost for any of the labwork including FedExing samples to the research team.
Every participant will have a unique study identification to maintain privacy.
What is especially attractive about this study is the fact that any participant who wishes to have access to her individual results will be able to do so. Unfortunately this is not always the case with research projects.
Interested women can sign up here